The Effect Of Giving Nano Herbal Biwa Leaf (Eriobotrya japonica Lindl.) Against Histological Description Of Kidney Rat That Induced By Alloxan

Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to abnormal insulin secretion and action. Uncontrolled diabetes will cause various organ complications, one of which diabetic nephropathy or kidney failure. The aim this study was determine the effect nano herbal biwa leaves (Eriobotrya japonica) on structure gromerulus, renal necrosis, proximal tubular constriction, weight discoloration. This uses an analytic with true experimental design in male rats (Rattus norvegicus) consisting five treatments each six replications. consisted negative control group that only given ad-libitum feed, positive injected alloxan, two groups alloxan 250 mg/kg 500 nanoherbal. It concluded nanoherbal effective enough reduce blood glucose levels safe for consumption diabetics because it does not damage cells.